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	graft versus host disease

Disease ID	556
Disease	graft versus host disease
Definition	The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Synonym	autoimmune foreign transplant disease disease graft host versus disease graft host vs disease graft versus host disease, graft-versus-host disease, graft-vs-host disease, homologous wasting disease, runt diseases, graft-versus-host diseases, graft-vs-host graft versus host dis graft versus host disease (disorder) graft versus host disease [ambiguous] graft versus host disease, nos graft vs host dis graft vs host disease graft vs host disease [disease/finding] graft vs. host disease graft-versus-host disease graft-versus-host disease (disorder) graft-versus-host disease, unspecified graft-versus-host diseases graft-versus-host nos graft-versus-host-disease graft-vs-host disease graft-vs-host diseases gvh gvh disease gvhd gvhd - graft-versus-host disease homol wasting dis homologous wasting disease host versus graft disease host vs graft disease runt dis runt disease runting syndrome
Orphanet	ORPHANET:39812
ICD10	ICD10CM:D89.813
UMLS	C0018133
MeSH	D006086
SNOMED-CT	SNOMEDCT_US_2016_09_01:234646005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:118) C0023418 \| leukemia \| 11 C0314719 \| dry eye \| 9 C0011991 \| diarrhea \| 6 C0026946 \| fungal infection \| 5 C0026946 \| fungal infections \| 4 C0026764 \| myeloma \| 4 C0026764 \| multiple myeloma \| 4 C0376545 \| hematological malignancies \| 4 C0026986 \| myelodysplastic syndrome \| 4 C0085669 \| acute leukemia \| 4 C0022658 \| nephropathy \| 3 C0013238 \| dry eye syndrome \| 3 C0155765 \| microangiopathy \| 3 C0015625 \| fanconi anemia \| 3 C0002871 \| anemia \| 3 C0042769 \| viral infection \| 3 C0032285 \| pneumonia \| 3 C0011991 \| diarrhoea \| 3 C0006272 \| bronchiolitis obliterans \| 3 C0020443 \| hypercholesterolemia \| 2 C0152025 \| polyneuropathy \| 2 C0015230 \| exanthema \| 2 C0023418 \| leukaemia \| 2 C0042769 \| viral infections \| 2 C0558353 \| tongue carcinoma \| 2 C0023890 \| cirrhosis \| 2 C0024523 \| malabsorption \| 2 C0023470 \| myeloid leukemia \| 2 C0002874 \| aplastic anemia \| 2 C0006271 \| bronchiolitis \| 2 C0030312 \| pancytopenia \| 2 C0015230 \| rash \| 2 C0023467 \| acute myeloid leukemia \| 2 C1145670 \| respiratory failure \| 2 C0011644 \| scleroderma \| 2 C0017665 \| membranous nephropathy \| 2 C0042769 \| virus infection \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0030804 \| mucous membrane pemphigoid \| 1 C0002874 \| aplastic anaemia \| 1 C0085669 \| acute leukemias \| 1 C0014527 \| epidermolysis bullosa \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0010930 \| dacryocystitis \| 1 C0376545 \| hematologic malignancies \| 1 C0017160 \| gastroenteritis \| 1 C0022575 \| keratoconjunctivitis sicca \| 1 C0004030 \| aspergillosis \| 1 C0019069 \| hemophilia \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0024115 \| lung disease \| 1 C0023448 \| lymphocytic leukemia \| 1 C0007134 \| renal cell carcinoma \| 1 C0034150 \| purpura \| 1 C1527407 \| eosinophilic pneumonia \| 1 C0011334 \| dental caries \| 1 C0024523 \| malabsorption syndrome \| 1 C0008370 \| cholestasis \| 1 C0020538 \| hypertension \| 1 C0030805 \| pemphigoid \| 1 C0085110 \| severe combined immunodefic \| 1 C0023418 \| leukemias \| 1 C0021843 \| bowel obstruction \| 1 C1258215 \| ileus \| 1 C0007177 \| cardiac tamponade \| 1 C0031046 \| pericarditis \| 1 C0015397 \| eye disease \| 1 C0030305 \| pancreatitis \| 1 C0043541 \| zygomycosis \| 1 C0085110 \| severe combined immunodeficiency \| 1 C0002438 \| amoebiasis \| 1 C0007137 \| squamous cell carcinoma \| 1 C0346054 \| verruciform xanthoma \| 1 C0009319 \| colitis \| 1 C0011334 \| caries \| 1 C0086543 \| cataract \| 1 C0023470 \| myeloid leukaemia \| 1 C0031048 \| constrictive pericarditis \| 1 C0026946 \| fungal disease \| 1 C0376545 \| hematologic cancer \| 1 C0151546 \| carcinoma of the oral cavity \| 1 C0021053 \| immune disease \| 1 C0023467 \| acute myeloid leukaemia \| 1 C1955861 \| t-cell large granular lymphocyte leukemia \| 1 C0027726 \| nephrotic syndrome \| 1 C0041351 \| tularemia \| 1 C0040100 \| thymoma \| 1 C0013418 \| abnormal labor \| 1 C0004623 \| bacterial infection \| 1 C0162855 \| mucinosis \| 1 C0442874 \| neuropathy \| 1 C0085669 \| acute leukaemia \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0026764 \| plasma cell myeloma \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0878544 \| cardiomyopathy \| 1 C0155237 \| acute dacryocystitis \| 1 C0033680 \| protein losing enteropathy \| 1 C1568868 \| oral mucositis \| 1 C0002170 \| alopecia \| 1 C0600260 \| obstructive lung disease \| 1 C0008312 \| biliary cirrhosis \| 1 C0002171 \| alopecia areata \| 1 C0031117 \| peripheral neuropathy \| 1 C0035305 \| retinal detachment \| 1 C0037199 \| sinusitis \| 1 C0024523 \| malabsorption syndromes \| 1 C0013370 \| intestinal amoebiasis \| 1 C0242770 \| bronchiolitis obliterans organizing pneumonia \| 1 C0032285 \| pneumonitis \| 1 C0032326 \| pneumothorax \| 1 C0022573 \| keratoconjunctivitis \| 1 C0013182 \| drug hypersensitivity \| 1 C0085655 \| polymyositis \| 1 C0023646 \| lichen planus \| 1 C0020541 \| portal hypertension \| 1 C0162429 \| malnutrition \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 4524 \| MTHFR \| CTD_human 3458 \| IFNG \| CTD_human 1493 \| CTLA4 \| CTD_human 3605 \| IL17A \| CTD_human 7367 \| UGT2B17 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:101) 1234 \| CCR5 \| CIPHER 1493 \| CTLA4 \| CIPHER;CTD_human 2212 \| FCGR2A \| CIPHER 3458 \| IFNG \| CIPHER;CTD_human 3586 \| IL10 \| CIPHER 3552 \| IL1A \| CIPHER 3553 \| IL1B \| CIPHER 3557 \| IL1RN \| CIPHER 3565 \| IL4 \| CIPHER 3569 \| IL6 \| CIPHER 3802 \| KIR2DL1 \| CIPHER 3803 \| KIR2DL2 \| CIPHER 3804 \| KIR2DL3 \| CIPHER 3805 \| KIR2DL4 \| CIPHER 3806 \| KIR2DS1 \| CIPHER 3808 \| KIR2DS3 \| CIPHER 3810 \| KIR2DS5 \| CIPHER 3811 \| KIR3DL1 \| CIPHER 3812 \| KIR3DL2 \| CIPHER 7040 \| TGFB1 \| CIPHER 7124 \| TNF \| CIPHER 11214 \| AKAP13 \| CIPHER 328 \| APEX1 \| CIPHER 597 \| BCL2A1 \| CIPHER 6347 \| CCL2 \| CIPHER 6352 \| CCL5 \| CIPHER 2237 \| FEN1 \| CIPHER 3105 \| HLA-A \| CIPHER 3106 \| HLA-B \| CIPHER 3107 \| HLA-C \| CIPHER 3115 \| HLA-DPB1 \| CIPHER 3117 \| HLA-DQA1 \| CIPHER 3119 \| HLA-DQB1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 3133 \| HLA-E \| CIPHER 57824 \| HMHB1 \| CIPHER 3439 \| IFNA1 \| CIPHER 3588 \| IL10RB \| CIPHER 149233 \| IL23R \| CIPHER 3813 \| KIR3DS1 \| CIPHER 3938 \| LCT \| CIPHER 3978 \| LIG1 \| CIPHER 3980 \| LIG3 \| CIPHER 4049 \| LTA \| CIPHER 8174 \| MADCAM1 \| CIPHER 8930 \| MBD4 \| CIPHER 4350 \| MPG \| CIPHER 4524 \| MTHFR \| CIPHER;CTD_human 4595 \| MUTYH \| CIPHER 64005 \| MYO1G \| CIPHER 64127 \| NOD2 \| CIPHER 4913 \| NTHL1 \| CIPHER 4968 \| OGG1 \| CIPHER 142 \| PARP1 \| CIPHER 5111 \| PCNA \| CIPHER 5175 \| PECAM1 \| CIPHER 11284 \| PNKP \| CIPHER 5423 \| POLB \| CIPHER 5424 \| POLD1 \| CIPHER 5425 \| POLD2 \| CIPHER 5426 \| POLE \| CIPHER 11201 \| POLI \| CIPHER 5981 \| RFC1 \| CIPHER 5982 \| RFC2 \| CIPHER 5983 \| RFC3 \| CIPHER 5984 \| RFC4 \| CIPHER 5985 \| RFC5 \| CIPHER 4088 \| SMAD3 \| CIPHER 23583 \| SMUG1 \| CIPHER 3431 \| SP110 \| CIPHER 6996 \| TDG \| CIPHER 7132 \| TNFRSF1A \| CIPHER 7133 \| TNFRSF1B \| CIPHER 7367 \| UGT2B17 \| CIPHER;CTD_human 7374 \| UNG \| CIPHER 7421 \| VDR \| CIPHER 7515 \| XRCC1 \| CIPHER 5243 \| ABCB1 \| CIPHER 28 \| ABO \| CIPHER 1636 \| ACE \| CIPHER 183 \| AGT \| CIPHER 185 \| AGTR1 \| CIPHER 186 \| AGTR2 \| CIPHER 1577 \| CYP3A5 \| CIPHER 2099 \| ESR1 \| CIPHER 2100 \| ESR2 \| CIPHER 2938 \| GSTA1 \| CIPHER 3136 \| HLA-H \| CIPHER 3305 \| HSPA1L \| CIPHER 3460 \| IFNGR2 \| CIPHER 3554 \| IL1R1 \| CIPHER 3558 \| IL2 \| CIPHER 3566 \| IL4R \| CIPHER 3659 \| IRF1 \| CIPHER 4509 \| MT-ATP8 \| CIPHER 4537 \| MT-ND3 \| CIPHER 5027 \| P2RX7 \| CIPHER 7042 \| TGFB2 \| CIPHER 7099 \| TLR4 \| CIPHER 7298 \| TYMS \| CIPHER 3605 \| IL17A \| CTD_human
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	556
Disease	graft versus host disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:101) HP:0001909 \| Leukemia \| 10 HP:0002664 \| Neoplasia \| 9 HP:0002014 \| Diarrhea \| 6 HP:0030731 \| Carcinoma \| 5 HP:0001824 \| Weight loss \| 4 HP:0002863 \| Myelodysplastic syndrome \| 4 HP:0002488 \| Acute leukemias \| 4 HP:0006775 \| Multiple myeloma \| 4 HP:0001903 \| Anemia \| 3 HP:0000112 \| Nephropathy \| 3 HP:0001399 \| Liver failure \| 3 HP:0011946 \| Constrictive bronchiolitis \| 3 HP:0002090 \| Pneumonia \| 3 HP:0002878 \| Respiratory failure \| 2 HP:0012324 \| Myeloid leukemia \| 2 HP:0000988 \| Exanthem \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0003124 \| Elevated serum cholesterol \| 2 HP:0000969 \| Dropsy \| 2 HP:0001880 \| Eosinophilia \| 2 HP:0011950 \| Bronchiolitis \| 2 HP:0012531 \| Pain \| 2 HP:0004808 \| Acute myelogenous leukemia \| 2 HP:0001596 \| Hair loss \| 2 HP:0012578 \| Membranous glomerulonephritis \| 2 HP:0001271 \| Polyneuropathy \| 2 HP:0100806 \| Sepsis \| 2 HP:0100324 \| Progressive systemic scleroderma \| 2 HP:0002024 \| Intestinal malabsorption \| 2 HP:0001915 \| Aplastic anemia \| 2 HP:0002107 \| Collapsed lung \| 1 HP:0001114 \| Fatty deposits on eyelids \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0000541 \| Detached retina \| 1 HP:0007468 \| Perifollicular hyperkeratosis \| 1 HP:0004395 \| Malnutrition \| 1 HP:0000822 \| Hypertension \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0001250 \| Seizures \| 1 HP:0001396 \| Cholestasis \| 1 HP:0002665 \| Lymphoma \| 1 HP:0100522 \| Thymoma \| 1 HP:0040186 \| Maculopapular exanthema \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0001097 \| Keratoconjunctivitis sicca \| 1 HP:0002229 \| Alopecia areata \| 1 HP:0001701 \| Pericarditis \| 1 HP:0001875 \| Neutropenia \| 1 HP:0007663 \| Central visual loss \| 1 HP:0005200 \| Retroperitoneal fibrosis \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0000217 \| Dry mouth syndrome \| 1 HP:0200034 \| Papule \| 1 HP:0002013 \| Emesis \| 1 HP:0002018 \| Nausea \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0002958 \| Immune dysregulation \| 1 HP:0002039 \| Anorexia \| 1 HP:0000670 \| Dental caries \| 1 HP:0100583 \| Corneal perforation \| 1 HP:0004430 \| Severe combined immunodeficiency \| 1 HP:0001945 \| Fever \| 1 HP:0012378 \| Fatigue \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0200016 \| Acral keratosis \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0000518 \| Cataract \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0045073 \| Serositis \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0011945 \| Cryptogenic organizing pneumonia \| 1 HP:0000979 \| Purpura \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001746 \| Absent spleen \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0002563 \| Constrictive pericarditis \| 1 HP:0007502 \| Hyperkeratosis follicularis \| 1 HP:0003394 \| Muscle cramps \| 1 HP:0005132 \| Pericardial constriction \| 1 HP:0000620 \| Dacrocystitis \| 1 HP:0007133 \| Progressive peripheral neuropathy \| 1 HP:0002583 \| Colitis \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0001371 \| Flexion contractures of joints \| 1 HP:0006536 \| Obstructive lung disease \| 1 HP:0001019 \| Exfoliative dermititis \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0001096 \| Keratoconjunctivitis \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0001259 \| Coma \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0001409 \| Portal hypertension \| 1

Disease ID	556
Disease	graft versus host disease
Manually Symptom	UMLS \| Name(Total Manually Symptoms:11) C2364133 \| infection C1555769 \| pulmonary disease C0752303 \| urological manifestation C0585362 \| squamous cell carcinoma of the oral cavity C0314719 \| dry eye C0040261 \| onychomycosis C0037284 \| skin lesions C0029166 \| oral manifestations C0014034 \| enanthema C0008370 \| cholestasis C0001883 \| airways obstruction
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0314719 \| dry eye \| 8 C0426768 \| o sign \| 5 C0023418 \| leukemia \| 4 C0029166 \| oral manifestations \| 2 C0026946 \| fungal infections \| 2 C0270922 \| demyelinating polyneuropathy \| 1 C0009450 \| infection \| 1 C0043541 \| zygomycosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1061622	14688526	7133	TNFRSF1B	umls:C0018133	BeFree	Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation.	0.010639772	2003	TNFRSF1B	1	12192898	T	G
rs2275913	22028838	3605	IL17A	umls:C0018133	BeFree	When we examined the impact of rs2275913 in a cohort consisting of 438 pairs of patients and their unrelated donors transplanted through the Japan Marrow Donor Program, the donor IL-17 197A allele was found to be associated with a higher risk of acute graft-versus-host disease (GVHD; hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.00 to 2.13; P = 0.05).	0.120814326	2011	IL17A	6	52186235	G	A
rs4693608	24319286	10855	HPSE	umls:C0018133	BeFree	The study emphasizes the importance of rs4693608 SNP for HPSE gene expression in activated MNCs, indicating a role in allogeneic stem cell transplantation, including postconditioning, engraftment, and GVHD.	0.003181358	2014	HPSE	4	83320204	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	556
Disease	graft versus host disease
Case	(Waiting for update.)

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